Sertraline

Sertraline
Clinical data
Trade names	Zoloft (左洛復), 彼邁樂 , Lustral téng
AHFS/Drugs.com	Monograph
MedlinePlus	a697048
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ; ;
Routes of; administration	kháu-ho̍k
ATC code	N06AB06 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	44%
Protein binding	98.5%
Metabolism	koaⁿ-chōng
Elimination half-life	~23-26 tiám-cheng (Ke hoa̍t-sèng ê tāi-siā sán-bu̍t Norsertraline sī 66 tiám-cheng)
Excretion	jiō-e̍k
Identifiers
	IUPAC name (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;
CAS Number	79617-96-2 ;
PubChem CID	68617;
DrugBank	DB01104 ;
ChemSpider	61881 ;
UNII	QUC7NX6WMB;
KEGG	D02360 ;
ChEBI	CHEBI:9123 ;
ChEMBL	CHEMBL809 ;
Chemical and physical data
Formula	C17H17Cl2N
Molar mass	306.229 g/mol
3D model (JSmol)	Interactive image;
	SMILES ClC1=CC=C([C@H]2C3=C([C@H](CC2)NC)C=CC=C3)C=C1Cl;
	InChI InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m0/s1 ; Key:VGKDLMBJGBXTGI-SJCJKPOMSA-N ;
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Sertraline mā kiò chò Sià-khiok-lîm (舍曲林) , ia̍h ū Zoloft ê siong-phín miâ, sī chi̍t chióng sóan-te̍k-sèng huih-chheng-sò͘ chài-liap-chhú ek-chè-chè lūi ê khòng ek-ut io̍h-bu̍t, tī 1991 nî iû Pfizer chè-io̍h kong-su hoat-bêng.

Sèng-chit

Sertraline sī pe̍h-sek, bâ-bui iûⁿ î chúi ê kiat-chiⁿ.

↑ drugs.com drugs.com international Sertraline Page accessed May 11, 2015
↑ Obach RS, Cox LM, Tremaine LM (2005). "Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study". Drug Metab. Dispos. 33 (2): 262–70. doi:10.1124/dmd.104.002428. PMID 15547048.
↑ Sertraline FDA Label. http://www.fda.gov/ohrms/dockets/ac/04/briefing/4006b1_06_zoloft-label.pdf
↑ Brunton L, Chabner B, Knollman B. Goodman and Gilman’s The Pharmacological Basis of Therapeutics, Twelfth Edition. McGraw Hill Professional; 2010.

Clinical data


Trade names	Zoloft (左洛復), 彼邁樂 , Lustral téng^[1]
AHFS/Drugs.com	Monograph
MedlinePlus	a697048
Pregnancy category	AU: C US: C (Risk not ruled out)
Routes of administration	kháu-ho̍k
ATC code	N06AB06 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	44%
Protein binding	98.5%
Metabolism	koaⁿ-chōng^[2]
Elimination half-life	~23-26 tiám-cheng (Ke hoa̍t-sèng ê tāi-siā sán-bu̍t Norsertraline sī 66 tiám-cheng)^[3]^[4]
Excretion	jiō-e̍k
Identifiers
IUPAC name (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
CAS Number	79617-96-2^Y
PubChem CID	68617
DrugBank	DB01104^Y
ChemSpider	61881^Y
UNII	QUC7NX6WMB
KEGG	D02360^Y
ChEBI	CHEBI:9123^Y
ChEMBL	CHEMBL809^Y
Chemical and physical data
Formula	C₁₇H₁₇Cl₂N
Molar mass	306.229 g/mol
3D model (JSmol)	Interactive image
SMILES ClC1=CC=C([C@H]2C3=C([C@H](CC2)NC)C=CC=C3)C=C1Cl
InChI InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m0/s1^Y Key:VGKDLMBJGBXTGI-SJCJKPOMSA-N^Y
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