Sertraline

Sertraline mā kiò chò Sià-khiok-lîm (舍曲林) , ia̍h ū Zoloft ê siong-phín miâ, sī chi̍t chióng sóan-te̍k-sèng huih-chheng-sò͘ chài-liap-chhú ek-chè-chè lūi ê khòng ek-ut io̍h-bu̍t, tī 1991 nî iû Pfizer chè-io̍h kong-su hoat-bêng.

Sertraline
Sertraline2DACS2.svg
Sertraline-3D-balls.png
Clinical data
Trade names Zoloft (左洛復), 彼邁樂 , Lustral téng[1]
AHFS/Drugs.com Pang-bô͘:Drugs.com
MedlinePlus a697048
Pregnancy
category
  • AU: C
  • US: C (Risk not ruled out)
Routes of
administration
kháu-ho̍k
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability 44%
Protein binding 98.5%
Metabolism koaⁿ-chōng[2]
Elimination half-life ~23-26 tiám-cheng (Ke hoa̍t-sèng ê tāi-siā sán-bu̍t Norsertraline sī 66 tiám-cheng)[3][4]
Excretion jiō-e̍k
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
Formula C17H17Cl2N
Molar mass 306.229 g/mol
3D model (JSmol)
  (verify)

Sèng-chit修改

Sertraline sī pe̍h-sek, bâ-bui iûⁿ î chúi ê kiat-chiⁿ.

  1. drugs.com drugs.com international Sertraline Page accessed May 11, 2015
  2. Obach RS, Cox LM, Tremaine LM (2005). "Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study". Drug Metab. Dispos. 33 (2): 262–70. doi:10.1124/dmd.104.002428. PMID 15547048. 
  3. Sertraline FDA Label. http://www.fda.gov/ohrms/dockets/ac/04/briefing/4006b1_06_zoloft-label.pdf
  4. Brunton L, Chabner B, Knollman B. Goodman and Gilman’s The Pharmacological Basis of Therapeutics, Twelfth Edition. McGraw Hill Professional; 2010.